Positive family history of essential tremor influences the motor phenotype of Parkinson's disease
Identifieur interne : 002131 ( Main/Exploration ); précédent : 002130; suivant : 002132Positive family history of essential tremor influences the motor phenotype of Parkinson's disease
Auteurs : Peter Hedera [États-Unis] ; John Y. Fang [États-Unis] ; Fenna Phibbs [États-Unis] ; Michael K. Cooper [États-Unis] ; P. David Charles [États-Unis] ; Thomas L. Davis [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Aged, Disability Evaluation, Essential Tremor (complications), Family Health, Female, Humans, Male, Middle Aged, Nervous system diseases, Parkinson Disease (etiology), Parkinson disease, Parkinson's disease, Phenotype, Postural Balance (physiology), Risk Factors, Severity of Illness Index, Tremor, autosomal dominant inheritance, essential tremor, genetics.
- MESH :
- complications : Essential Tremor.
- etiology : Parkinson Disease.
- physiology : Postural Balance.
- Aged, Disability Evaluation, Family Health, Female, Humans, Male, Middle Aged, Phenotype, Risk Factors, Severity of Illness Index.
Abstract
Previous reports have suggested that essential tremor (ET) represents a risk factor for the development of Parkinson's disease (PD). Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22772
Affiliations:
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Patients with long‐standing ET who develop PD tend to have a tremor‐dominant subtype. To further clarify this association, we examined patients from kindreds with autosomal dominant ET who had signs of isolated PD but did not meet criteria for overlapping ET. We identified 22 patients with PD meeting these diagnostic criteria, and 90% (20 of 22) had tremor‐predominant subtype of PD. Unilateral rest tremor was the presenting symptom in 15 of 22 patients, bradykinesia or rigidity in 5 of 22, and gait problems in 2 of 22. Postural tremor was relatively mild, and the severity of kinetic tremor tightly correlated with rest tremor (r = 0.83, P < 0.001). Tremor‐dominant subtype of PD in patients with a positive family history of ET suggests that these patients have inherited a genetic susceptibility factor for tremor, which affects the motor phenotype of PD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Tennessee</li></region></list><tree><country name="États-Unis"><region name="Tennessee"><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name></region><name sortKey="Charles, P David" sort="Charles, P David" uniqKey="Charles P" first="P. David" last="Charles">P. David Charles</name><name sortKey="Cooper, Michael K" sort="Cooper, Michael K" uniqKey="Cooper M" first="Michael K." last="Cooper">Michael K. Cooper</name><name sortKey="Davis, Thomas L" sort="Davis, Thomas L" uniqKey="Davis T" first="Thomas L." last="Davis">Thomas L. Davis</name><name sortKey="Fang, John Y" sort="Fang, John Y" uniqKey="Fang J" first="John Y." last="Fang">John Y. Fang</name><name sortKey="Hedera, Peter" sort="Hedera, Peter" uniqKey="Hedera P" first="Peter" last="Hedera">Peter Hedera</name><name sortKey="Phibbs, Fenna" sort="Phibbs, Fenna" uniqKey="Phibbs F" first="Fenna" last="Phibbs">Fenna Phibbs</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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